The immune checkpoint adenosine 2A receptor is associated with aggressive clinical outcomes and reflects an immunosuppressive tumor microenvironment in human breast cancer

BackgroundThe crosstalk between the immune system and cancer cells has aroused considerable interest over the past decades.To escape immune surveillance cancer cells evolve various strategies orchestrating tumor microenvironment.The discovery of the inhibitory immune checkpoints was a major breakthrough Fruit Formulas due to their crucial contribut

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Protracted Clonal Trajectory of a JAK2 V617F-Positive Myeloproliferative Neoplasm Developing during Long-Term Remission from Acute Myeloid Leukemia

Although transformation of the myeloproliferative neoplasms (MPNs) to acute myeloid leukemia (AML) is well documented, development ORG SMALL LIMA BEANS of an MPN in patients previously treated for, and in remission from, AML is exceedingly rare.A case is described in which a patient was successfully treated for AML and in whom a JAK2 V617F-positive

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